Association between somatic microsatellite instability, hypermutation status, and specific T cell subsets in colorectal cancer tumors

BackgroundMicrosatellite instability-high (MSI-high) tumors comprise ~15% of sporadic colorectal cancers (CRC) and are associated with elevated T cell infiltration. However, the universality of this response across T cell subtypes with distinct functions is unknown.MethodsIncluding 1,236 CRC tumors...

Olles dieđut

Bibliográfalaš dieđut

Váldodahkkit:	Claire E. Thomas, Yasutoshi Takashima, Evertine Wesselink, Tomotaka Ugai, Robert S. Steinfelder, Daniel D. Buchanan, Conghui Qu, Li Hsu, Andressa Dias Costa, Steven Gallinger, Robert C. Grant, Jeroen R. Huyghe, Sushma S. Thomas, Shuji Ogino, Amanda I. Phipps, Jonathan A. Nowak, Ulrike Peters
Materiálatiipa:	Artigo
Giella:	Inglês
Almmustuhtton:	Frontiers Media S.A. 2024-12-01
Ráidu:	Frontiers in Immunology
Fáttát:	microsatellite instability hypermutation DNA mismatch repair T cells epithelial stromal
Liŋkkat:	https://www.frontiersin.org/articles/10.3389/fimmu.2024.1505896/full
Fáddágilkorat:	Lasit fáddágilkoriid Eai fáddágilkorat, Lasit vuosttaš fáddágilkora!