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Senolysis of gemcitabine‐induced senescent human pancreatic cancer cells

Abstract Introduction Gemcitabine (GEM) is often used to treat pancreatic cancer. Many anti‐cancer drugs induce cancer cell death, but some cells survive after cell cycle arrest. Such a response to DNA damage is termed cellular senescence. Certain drugs, including the Bcl‐2‐family inhibitor ABT‐263,...

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Principais autores: Mohammad Mahbubul Hoque, Yuichi Iida, Hitoshi Kotani, Mamoru Harada
Format: Artigo
Sprog:Inglês
Udgivet: Wiley 2024-04-01
Serier:Cancer Reports
Fag:
Bcl‐xL
gemcitabine
pancreatic cancer
senescence
senolysis
Online adgang:https://doi.org/10.1002/cnr2.2075
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