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Enhanced Medial Prefrontal Cortex and Hippocampal Activity Improves Memory Generalization in APP/PS1 Mice: A Multimodal Animal MRI Study

Memory generalization allows individuals to extend previously learned movement patterns to similar environments, contributing to cognitive flexibility. In Alzheimer’s disease (AD), the disturbance of generalization is responsible for the deficits of episodic memory, causing patients with AD to forge...

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Uloženo v:
Hlavní autoři: Weilin Liu, Jianhong Li, Le Li, Yuhao Zhang, Minguang Yang, Shengxiang Liang, Long Li, Yaling Dai, Lewen Chen, Weiwei Jia, Xiaojun He, Huawei Lin, Jing Tao
Médium: Artigo
Jazyk:Inglês
Vydáno: Frontiers Media S.A. 2022-03-01
Edice:Frontiers in Cellular Neuroscience
Témata:
Alzheimer’s disease
cognitive training
generalization
functional activity
neurochemical metabolism
On-line přístup:https://www.frontiersin.org/articles/10.3389/fncel.2022.848967/full
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