Recombination Is Responsible for the Increased Recovery of Drug-Resistant Mutants with Hypermutated Genomes in Resting Yeast Diploids Expressing APOBEC Deaminases

DNA editing deaminases (APOBECs) are implicated in generation of mutations in somatic cells during tumorigenesis. APOBEC-dependent mutagenesis is thought to occur during transient exposure of unprotected single-stranded DNA. Mutations frequently occur in clusters (kataegis). We investigated mechanis...

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Autors principals:	Artem G. Lada, Elena I. Stepchenkova, Anna S. Zhuk, Sergei F. Kliver, Igor B. Rogozin, Dmitrii E. Polev, Alok Dhar, Youri I. Pavlov
Format:	Artigo
Idioma:	Inglês
Publicat:	Frontiers Media S.A. 2017-12-01
Col·lecció:	Frontiers in Genetics
Matèries:	APOBECs kataegis mutants in resting diploid yeast recombination next generation sequencing tumorigenesis
Accés en línia:	http://journal.frontiersin.org/article/10.3389/fgene.2017.00202/full
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