Transcriptional vulnerabilities of striatal neurons in human and rodent models of Huntington’s disease

In human and mouse models of Huntington’s disease, Matsushima, Pineda et al. show, using snRNAsequencing, the two axes defining identities of striatal projection neurons are multiplexed and differentially compromised, calling for distinct therapies.

Bibliografiske detaljer

Principais autores:	Ayano Matsushima, Sergio Sebastian Pineda, Jill R. Crittenden, Hyeseung Lee, Kyriakitsa Galani, Julio Mantero, Geoffrey Tombaugh, Manolis Kellis, Myriam Heiman, Ann M. Graybiel
Format:	Artigo
Sprog:	Inglês
Udgivet:	Nature Portfolio 2023-01-01
Serier:	Nature Communications
Online adgang:	https://doi.org/10.1038/s41467-022-35752-x
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