Wdr1-Dependent Actin Reorganization in Platelet Activation.
In resting platelets, the integrin αIIbβ3 is present in a low-affinity "bent" state. During platelet aggregation, intracytoplasmic signals induce conformational changes (inside-out signaling) that result in a "swung-out" conformation competent to bind ligands such as fibrinogen. The cytoskeleton pla...
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| Glavni autori: | , , , , , |
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| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
Public Library of Science (PLoS)
2016-01-01
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| Serija: | PLoS ONE |
| Online pristup: | http://europepmc.org/articles/PMC5023164?pdf=render |
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