Rho-Kinase Inhibition Ameliorates Dasatinib-Induced Endothelial Dysfunction and Pulmonary Hypertension

The multi-kinase inhibitor dasatinib is used for treatment of imatinib-resistant chronic myeloid leukemia, but is prone to induce microvascular dysfunction. In lung this can manifest as capillary leakage with pleural effusion, pulmonary edema or even pulmonary arterial hypertension. To understand ho...

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Hlavní autoři:	Csilla Fazakas, Chandran Nagaraj, Diana Zabini, Attila G. Végh, Leigh M. Marsh, Imola Wilhelm, István A. Krizbai, Horst Olschewski, Andrea Olschewski, Zoltán Bálint
Médium:	Artigo
Jazyk:	Inglês
Vydáno:	Frontiers Media S.A. 2018-05-01
Edice:	Frontiers in Physiology
Témata:	endothelial cells paracellular permeability dasatinib Rho-kinase pulmonary arterial hypertension endothelial elasticity
On-line přístup:	http://journal.frontiersin.org/article/10.3389/fphys.2018.00537/full
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