Substituting Tyr138 in the active site loop of human phenylalanine hydroxylase affects catalysis and substrate activation

Mammalian phenylalanine hydroxylase (PAH) is a key enzyme in l‐phenylalanine (l‐Phe) metabolism and is active as a homotetramer. Biochemical and biophysical work has demonstrated that it cycles between two states with a variably low and a high activity, and that the substrate l‐Phe is the key player...

Popoln opis

Bibliografske podrobnosti

Principais autores:	João Leandro, Anne J. Stokka, Knut Teigen, Ole A. Andersen, Torgeir Flatmark
Format:	Artigo
Jezik:	Inglês
Izdano:	Wiley 2017-07-01
Serija:	FEBS Open Bio
Teme:	active site loop phenylalanine hydroxylase substrate activation
Online dostop:	https://doi.org/10.1002/2211-5463.12243
Oznake:	Označite Brez oznak, prvi označite!