Substituting Tyr138 in the active site loop of human phenylalanine hydroxylase affects catalysis and substrate activation
Mammalian phenylalanine hydroxylase (PAH) is a key enzyme in l‐phenylalanine (l‐Phe) metabolism and is active as a homotetramer. Biochemical and biophysical work has demonstrated that it cycles between two states with a variably low and a high activity, and that the substrate l‐Phe is the key player...
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| Principais autores: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Wiley
2017-07-01
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| coleção: | FEBS Open Bio |
| Assuntos: | |
| Acesso em linha: | https://doi.org/10.1002/2211-5463.12243 |
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