PNC-27, a Chimeric p53-Penetratin Peptide Binds to HDM-2 in a p53 Peptide-like Structure, Induces Selective Membrane-Pore Formation and Leads to Cancer Cell Lysis

PNC-27, a 32-residue peptide that contains an HDM-2 binding domain and a cell-penetrating peptide (CPP) leader sequence kills cancer, but not normal, cells by binding to HDM-2 associated with the plasma membrane and induces the formation of pores causing tumor cell lysis and necrosis. Conformational...

Fuld beskrivelse

Bibliografiske detaljer

Principais autores:	Ehsan Sarafraz-Yazdi, Stephen Mumin, Diana Cheung, Daniel Fridman, Brian Lin, Lawrence Wong, Ramon Rosal, Rebecca Rudolph, Matthew Frenkel, Anusha Thadi, William F. Morano, Wilbur B. Bowne, Matthew R. Pincus, Josef Michl
Format:	Artigo
Sprog:	Inglês
Udgivet:	MDPI AG 2022-04-01
Serier:	Biomedicines
Fag:	PNC-27 p53 binding domain cell-penetrating peptides (CPP) HDM-2/MDM-2 plasma membrane pore formation
Online adgang:	https://www.mdpi.com/2227-9059/10/5/945
Tags:	Tilføj Tag Ingen Tags, Vær først til at tagge denne postø!