PNC-27, a Chimeric p53-Penetratin Peptide Binds to HDM-2 in a p53 Peptide-like Structure, Induces Selective Membrane-Pore Formation and Leads to Cancer Cell Lysis

PNC-27, a 32-residue peptide that contains an HDM-2 binding domain and a cell-penetrating peptide (CPP) leader sequence kills cancer, but not normal, cells by binding to HDM-2 associated with the plasma membrane and induces the formation of pores causing tumor cell lysis and necrosis. Conformational...

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Principais autores:	Ehsan Sarafraz-Yazdi, Stephen Mumin, Diana Cheung, Daniel Fridman, Brian Lin, Lawrence Wong, Ramon Rosal, Rebecca Rudolph, Matthew Frenkel, Anusha Thadi, William F. Morano, Wilbur B. Bowne, Matthew R. Pincus, Josef Michl
Formato:	Artigo
Idioma:	Inglês
Publicado:	MDPI AG 2022-04-01
Series:	Biomedicines
Assuntos:	PNC-27 p53 binding domain cell-penetrating peptides (CPP) HDM-2/MDM-2 plasma membrane pore formation
Acceso en liña:	https://www.mdpi.com/2227-9059/10/5/945
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