Structural conservation of Lassa virus glycoproteins and recognition by neutralizing antibodies

Summary: Lassa fever is an acute hemorrhagic fever caused by the zoonotic Lassa virus (LASV). The LASV glycoprotein complex (GPC) mediates viral entry and is the sole target for neutralizing antibodies. Immunogen design is complicated by the metastable nature of recombinant GPCs and the antigenic di...

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Главные авторы:	Hailee R. Perrett, Philip J.M. Brouwer, Jonathan Hurtado, Maddy L. Newby, Lin Liu, Helena Müller-Kräuter, Sarah Müller Aguirre, Judith A. Burger, Joey H. Bouhuijs, Grace Gibson, Terrence Messmer, John S. Schieffelin, Aleksandar Antanasijevic, Geert-Jan Boons, Thomas Strecker, Max Crispin, Rogier W. Sanders, Bryan Briney, Andrew B. Ward
Формат:	Artigo
Язык:	Inglês
Опубликовано:	Elsevier 2023-05-01
Серии:	Cell Reports
Предметы:	CP: Immunology
Online-ссылка:	http://www.sciencedirect.com/science/article/pii/S2211124723005351
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