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Selective inhibition of N-linked glycosylation impairs receptor tyrosine kinase processing

Global inhibition of N-linked glycosylation broadly reduces glycan occupancy on glycoproteins, but identifying how this inhibition functionally impacts specific glycoproteins is challenging. This limits our understanding of pathogenesis in the congenital disorders of glycosylation (CDG). We used sel...

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Principais autores: Elsenoor Klaver, Peng Zhao, Melanie May, Heather Flanagan-Steet, Hudson H. Freeze, Reid Gilmore, Lance Wells, Joseph Contessa, Richard Steet
Format: Artigo
Sprog:Inglês
Udgivet: The Company of Biologists 2019-06-01
Serier:Disease Models & Mechanisms
Fag:
Congenital
Convertase
Glycoproteins
Oligosaccharyltransferase
Furin
PCSK5
INSR
IGF-1R
Protein processing
STT3B
Online adgang:http://dmm.biologists.org/content/12/6/dmm039602
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