Rapamycin suppresses rheumatoid arthritis fibroblast synovial cell proliferation and induces apoptosis via the AKT/mTORC1 pathway

Abstract Background Rheumatoid arthritis (RA) is an autoimmune disease characterized by the overproliferation of synovial fibroblast‐like synoviocytes (FLSs) in the lining, leading to chronic inflammation and progressive joint damage. RA pathogenesis involves lymphocyte infiltration, increased synov...

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Autors principals:	Shengxiao Zhang, Xiaorong Hu, Qinyi Su, Heyi Zhang, Ting Cheng, Jia Wang, Ruomeng Pei, Xin Li, Ruqi Zhang, Hongfang Shao, Caihong Wang, Xiaofeng Li
Format:	Artigo
Idioma:	Inglês
Publicat:	Wiley 2024-09-01
Col·lecció:	Rheumatology & Autoimmunity
Matèries:	apoptosis mTORC1 rapamycin rheumatoid arthritis synovial fibroblasts
Accés en línia:	https://doi.org/10.1002/rai2.12120
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