Rapamycin suppresses rheumatoid arthritis fibroblast synovial cell proliferation and induces apoptosis via the AKT/mTORC1 pathway

Abstract Background Rheumatoid arthritis (RA) is an autoimmune disease characterized by the overproliferation of synovial fibroblast‐like synoviocytes (FLSs) in the lining, leading to chronic inflammation and progressive joint damage. RA pathogenesis involves lymphocyte infiltration, increased synov...

Full description

Bibliographic Details

Main Authors:	Shengxiao Zhang, Xiaorong Hu, Qinyi Su, Heyi Zhang, Ting Cheng, Jia Wang, Ruomeng Pei, Xin Li, Ruqi Zhang, Hongfang Shao, Caihong Wang, Xiaofeng Li
Format:	Artigo
Language:	Inglês
Published:	Wiley 2024-09-01
Series:	Rheumatology & Autoimmunity
Subjects:	apoptosis mTORC1 rapamycin rheumatoid arthritis synovial fibroblasts
Online Access:	https://doi.org/10.1002/rai2.12120
Tags:	Add Tag No Tags, Be the first to tag this record!