Inhibition of Glycine Re-Uptake: A Potential Approach for Treating Pain by Augmenting Glycine-Mediated Spinal Neurotransmission and Blunting Central Nociceptive Signaling

Among the myriad of cellular and molecular processes identified as contributing to pathological pain, disinhibition of spinal cord nociceptive signaling to higher cortical centers plays a critical role. Importantly, evidence suggests that impaired glycinergic neurotransmission develops in the dorsal...

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Autor principal:	Christopher L. Cioffi
Formato:	Artigo
Lenguaje:	Inglês
Publicado:	MDPI AG 2021-06-01
Colección:	Biomolecules
Materias:	glycine GABA glycine transporter (GlyT) glycine receptor (GlyR) nociceptor <i>N</i>-methyl-<span style="font-variant: small-caps">d</span>-aspartate (NMDA) receptor
Acceso en línea:	https://www.mdpi.com/2218-273X/11/6/864
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