The MEK1/2-IRF4 axis fosters T follicular helper cell differentiationand antitumor humoral immune response

Abstract Background Emerging evidence has underscored the significance of antitumor humoral immunity, which is associated with the development of T follicular helper (Tfh) cell. However, the molecular mechanisms underlying Tfh differentiation in antitumor immunity remains poorly understood. Methods...

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Detalhes bibliográficos

Principais autores:	Shuan Ran, Song Wang, Ran Li, Longyong Lai, Jizhang Yu, Xi Zhang, Yuan Li, Weicong Ye, Junjie Zong, Xiaohan Li, Yanglin Hao, Jiulu Zhao, Zilong Luo, Han Zhang, Kexiao Zheng, Pinyan Huang, Wang Zhan, Zifeng Zou, Yanqiang Zou, Jikai Cui, Jie Wu, Jiahong Xia
Formato:	Artigo
Idioma:	Inglês
Publicado em:	BMC 2026-03-01
coleção:	Journal of Translational Medicine
Assuntos:	Antitumor immunotherapy Humoral immunity T follicular helper cells Mitogen-activated protein kinase kinase 1/2 Interferon regulatory factor 4
Acesso em linha:	https://doi.org/10.1186/s12967-026-08023-2
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