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The MEK1/2-IRF4 axis fosters T follicular helper cell differentiationand antitumor humoral immune response

Abstract Background Emerging evidence has underscored the significance of antitumor humoral immunity, which is associated with the development of T follicular helper (Tfh) cell. However, the molecular mechanisms underlying Tfh differentiation in antitumor immunity remains poorly understood. Methods...

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Main Authors: Shuan Ran, Song Wang, Ran Li, Longyong Lai, Jizhang Yu, Xi Zhang, Yuan Li, Weicong Ye, Junjie Zong, Xiaohan Li, Yanglin Hao, Jiulu Zhao, Zilong Luo, Han Zhang, Kexiao Zheng, Pinyan Huang, Wang Zhan, Zifeng Zou, Yanqiang Zou, Jikai Cui, Jie Wu, Jiahong Xia
Format: Artigo
Language:Inglês
Published: BMC 2026-03-01
Series:Journal of Translational Medicine
Subjects:
Antitumor immunotherapy
Humoral immunity
T follicular helper cells
Mitogen-activated protein kinase kinase 1/2
Interferon regulatory factor 4
Online Access:https://doi.org/10.1186/s12967-026-08023-2
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