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Human UDP-Glucuronosyltransferase 2B4 and 2B7 Are Responsible for Naftopidil Glucuronidation in Vitro

Naftopidil (NAF) is widely used for the treatment of benign prostatic hyperplasia and prevention of prostate cancer in elderly men. These patients receive a combination of drugs, which involves high risk for drug–drug interaction. NAF exhibits superior efficacy but must be administered at a much hig...

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Main Authors: Xia-Wen Liu, Yi Rong, Xing-Fei Zhang, Jun-Jun Huang, Yi Cai, Bi-Yun Huang, Liu Zhu, Bo Wu, Ning Hou, Cheng-Feng Luo
Format: Artigo
Language:Inglês
Published: Frontiers Media S.A. 2018-01-01
Series:Frontiers in Pharmacology
Subjects:
naftopidil
enantiomer
metabolism
UDP-glucuronosyltransferases
microsomes
Online Access:http://journal.frontiersin.org/article/10.3389/fphar.2017.00984/full
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