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Endoplasmic reticulum anchored heme-oxygenase 1 faces the cytosol

Heme-oxygenase 1 is an endoplasmic reticulum-anchored enzyme that breaks down heme into iron, carbon monoxide and biliverdin. Heme is a hydrophobic co-factor in many proteins, including hemoglobin. Free heme is highly cytotoxic and, therefore, both heme synthesis and breakdown are tightly regulated....

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Autores principales: Yehonatan Gottlieb, Marianna Truman, Lyora A. Cohen, Yael Leichtmann-Bardoogo, Esther G. Meyron-Holtz
Formato: Artigo
Lenguaje:Inglês
Publicado: Ferrata Storti Foundation 2012-10-01
Colección:Haematologica
Acceso en línea:https://haematologica.org/article/view/6433
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