Heme cytotoxicity is the consequence of endoplasmic reticulum stress in atherosclerotic plaque progression

Abstract Hemorrhage and hemolysis with subsequent heme release are implicated in many pathologies. Endothelial cells (ECs) encounter large amount of free heme after hemolysis and are at risk of damage from exogenous heme. Here we show that hemorrhage aggravates endoplasmic reticulum (ER) stress in h...

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Bibliographic Details

Main Authors:	Dávid Pethő, Zoltán Hendrik, Annamária Nagy, Lívia Beke, Andreas Patsalos, László Nagy, Szilárd Póliska, Gábor Méhes, Csaba Tóth, László Potor, John W. Eaton, Harry S. Jacob, György Balla, József Balla, Tamás Gáll
Format:	Artigo
Language:	Inglês
Published:	Nature Portfolio 2021-05-01
Series:	Scientific Reports
Online Access:	https://doi.org/10.1038/s41598-021-89713-3
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