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Wavelet coherence phase analysis decodes the universal switching mechanism of Ras GTPase superfamily

Summary: The Ras superfamily of GTPases regulate critical cellular processes by shuttling between GTP-bound ON and GDP-bound OFF states. This switching mechanism is attributed to the conformational changes in two loops, SWI and SWII, upon GTP binding and hydrolysis. Since these conformational change...

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Bibliografiske detaljer
Principais autores: Zenia Motiwala, Anand S. Sandholu, Durba Sengupta, Kiran Kulkarni
Format: Artigo
Sprog:Inglês
Udgivet: Elsevier 2023-07-01
Serier:iScience
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Online adgang:http://www.sciencedirect.com/science/article/pii/S2589004223011082
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