In Vitro and In Silico Acetylcholinesterase Inhibitory Activity of Thalictricavine and Canadine and Their Predicted Penetration across the Blood-Brain Barrier

In recent studies, several alkaloids acting as cholinesterase inhibitors were isolated from <i>Corydalis cava</i> (Papaveraceae). Inhibitory activities of (+)-thalictricavine (<b>1</b>) and (+)-canadine (<b>2</b>) on human acetylcholinesterase (<i>h</i>AChE) and butyrylcholinesterase (<i>h</i>BChE)...

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Autores principales:	Jakub Chlebek, Jan Korábečný, Rafael Doležal, Šárka Štěpánková, Daniel I. Pérez, Anna Hošťálková, Lubomír Opletal, Lucie Cahlíková, Kateřina Macáková, Tomáš Kučera, Martina Hrabinová, Daniel Jun
Formato:	Artigo
Lenguaje:	Inglês
Publicado:	MDPI AG 2019-04-01
Colección:	Molecules
Materias:	(+)-thalictricavine (+)-canadine cholinesterases kinetic study molecular docking blood–brain barrier permeability
Acceso en línea:	https://www.mdpi.com/1420-3049/24/7/1340
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