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In Vitro and In Silico Acetylcholinesterase Inhibitory Activity of Thalictricavine and Canadine and Their Predicted Penetration across the Blood-Brain Barrier

In recent studies, several alkaloids acting as cholinesterase inhibitors were isolated from <i>Corydalis cava</i> (Papaveraceae). Inhibitory activities of (+)-thalictricavine (<b>1</b>) and (+)-canadine (<b>2</b>) on human acetylcholinesterase (<i>h</i>AChE) and butyrylcholinesterase (<i>h</i>BChE)...

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Principais autores: Jakub Chlebek, Jan Korábečný, Rafael Doležal, Šárka Štěpánková, Daniel I. Pérez, Anna Hošťálková, Lubomír Opletal, Lucie Cahlíková, Kateřina Macáková, Tomáš Kučera, Martina Hrabinová, Daniel Jun
Format: Artigo
Sprog:Inglês
Udgivet: MDPI AG 2019-04-01
Serier:Molecules
Fag:
(+)-thalictricavine
(+)-canadine
cholinesterases
kinetic study
molecular docking
blood–brain barrier permeability
Online adgang:https://www.mdpi.com/1420-3049/24/7/1340
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