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Polyclonal evolution of Fanconi anemia to MDS and AML revealed at single cell resolution

Abstract Background Fanconi anemia (FA) is a rare disease of bone marrow failure. FA patients are prone to develop myelodysplastic syndrome (MDS) and acute myeloid leukemia (AML). However, the molecular clonal evolution of the progression from FA to MDS/AML remains elusive. Methods Herein, we perfor...

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Hlavní autoři: Lixian Chang, Zejia Cui, Deyang Shi, Yajing Chu, Bichen Wang, Yang Wan, Qiuyi Ma, Ranran Zhang, Haoyuan Li, Xuelian Cheng, Tao Cheng, Xiaofan Zhu, Cheng Li, Weiping Yuan
Médium: Artigo
Jazyk:Inglês
Vydáno: BMC 2022-09-01
Edice:Experimental Hematology & Oncology
Témata:
Fanconi anemia
Myelodysplastic syndromes
Acute myeloid leukemia
Clonal evolution
On-line přístup:https://doi.org/10.1186/s40164-022-00319-5
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