Functional genomics and tumor microenvironment analysis reveal prognostic biological subtypes in Mantle cell lymphoma

Abstract Mantle cell lymphoma (MCL) is a genetically and clinically heterogeneous B-cell malignancy. We studied two MCL cohorts with differing treatment patterns: one enriched for immunochemotherapy, the other for chemotherapy alone. TP53 alterations are consistently associated with poor prognosis,...

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Principais autores:	Sunandini Sharma, Roshia Ali, Alyssa Bouska, Dylan Jochum, Meghana Kesireddy, Simeon Mahov, Joseph Lownik, Weiwei Zhang, Waseem Lone, Mahfuza Afroz Soma, Alicia Gamboa, Vaishnavi Devarakonda, Dalia El-Gamal, Atqiya Fariha, Adnan Mansoor, Douglas Stewart, Peter Martin, Brian K. Link, Ranjana H. Advani, Paul M. Barr, Andre H. Goy, Amitkumar Mehta, Manali Kamdar, Deborah M. Stephens, Veronika Bachanova, Lynette Smith, Ryan Morin, Prasath Pararajalingam, Matthew A. Lunning, Kai Fu, Dennis Weisenburger, Wing C. Chan, Joseph Khoury, Timothy C. Greiner, Julie M. Vose, Akil Merchant, Chengfeng Bi, Javeed Iqbal, On behalf of the North American Mantle Cell Lymphoma Project (NAMCLP)
Formato:	Artigo
Idioma:	Inglês
Publicado:	Nature Portfolio 2025-11-01
Series:	Nature Communications
Acceso en liña:	https://doi.org/10.1038/s41467-025-64666-7
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