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Sinapic Acid Reduces Oxidative Stress and Pyroptosis via Inhibition of BRD4 in Alcoholic Liver Disease

Alcoholic liver disease (ALD) is one of the main causes of death in chronic liver disease. Oxidative stress and pyroptosis are important factors leading to ALD. Bromodomain-containing protein 4 (BRD4) is a factor that we have confirmed to regulate ALD. As a phenolic acid compound, sinapic acid (SA)...

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Principais autores: Junyi Chu, Ran Yan, Sai Wang, Guoyang Li, Xiaohui Kang, Yan Hu, Musen Lin, Wen Shan, Yan Zhao, Zhecheng Wang, Ruimin Sun, Jihong Yao, Ning Zhang
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2021-06-01
coleção:Frontiers in Pharmacology
Assuntos:
alcoholic liver disease
sinapic acid
BRD4
oxidative stress
pyroptosis
Acesso em linha:https://www.frontiersin.org/articles/10.3389/fphar.2021.668708/full
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