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Reframing the link between metabolism and NLRP3 inflammasome: therapeutic opportunities

Inflammasomes are multiprotein signaling platforms in the cytosol that senses exogenous and endogenous danger signals and respond with the maturation and secretion of IL-1β and IL-18 and pyroptosis to induce inflammation and protect the host. The inflammasome best studied is the Nucleotide-binding o...

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Guardat en:
Autors principals: Miguel A. Ortega, Diego De Leon-Oliva, Cielo García-Montero, Oscar Fraile-Martinez, Diego Liviu Boaru, Amador Velazquez de Castro, Miguel A. Saez, Laura Lopez-Gonzalez, Julia Bujan, Miguel Angel Alvarez-Mon, Natalio García-Honduvilla, Raul Diaz-Pedrero, Melchor Alvarez-Mon
Format: Artigo
Idioma:Inglês
Publicat: Frontiers Media S.A. 2023-07-01
Col·lecció:Frontiers in Immunology
Matèries:
NLRP3 inflammasome
pyroptosis
mitochondrial dysfunction
mtROS
metabolic regulation
Accés en línia:https://www.frontiersin.org/articles/10.3389/fimmu.2023.1232629/full
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