Cyclophilin–CD147 interaction enables SARS-CoV-2 infection of human monocytes and their activation via Toll-like receptors 7 and 8

Monocytes and macrophages, as important constituents of the innate immune system, are equipped with multiple Toll-like-receptors (TLRs) to recognize invading pathogens, such as SARS-CoV-2, and mount an antiviral response. Nevertheless, their uncontrolled activation can lead to hyperinflammation seen...

Täydet tiedot

Bibliografiset tiedot

Päätekijät:	Gabor Tajti, Laura Gebetsberger, Gregor Pamlitschka, Katharina Aigner-Radakovics, Judith Leitner, Peter Steinberger, Hannes Stockinger, Anna Ohradanova-Repic
Aineistotyyppi:	Artigo
Kieli:	Inglês
Julkaistu:	Frontiers Media S.A. 2025-02-01
Sarja:	Frontiers in Immunology
Aiheet:	SARS-CoV-2 CD147 cyclophilin Toll-like receptor monocyte antiviral innate immunity
Linkit:	https://www.frontiersin.org/articles/10.3389/fimmu.2025.1460089/full
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