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Cyclophilin A secreted from fibroblast-like synoviocytes is involved in the induction of CD147 expression in macrophages of mice with collagen-induced arthritis

<p>Abstract</p> <p>Background</p> <p>Cyclophilin A (CypA), a member of the immunophilin family, is a ubiquitously distributed intracellular protein. Recent studies have shown that CypA is secreted by cells in response to inflammatory stimuli. Elevated levels of extracellular CypA and its receptor, C...

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Principais autores: Nishioku Tsuyoshi, Dohgu Shinya, Koga Mitsuhisa, Machida Takashi, Watanabe Takuya, Miura Teppei, Tsumagari Kousuke, Terasawa Mariko, Yamauchi Atsushi, Kataoka Yasufumi
Format: Artigo
Sprog:Inglês
Udgivet: BMC 2012-11-01
Serier:Journal of Inflammation
Fag:
CD147
Collagen-induced arthritis
Cyclophilin A
Macrophage
Rheumatoid arthritis
Online adgang:http://www.journal-inflammation.com/content/9/1/44
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