A C. elegans model of familial Alzheimer's disease shows age-dependent synaptic degeneration independent of amyloid β-peptide
The membrane-embedded γ-secretase complex is involved in the intramembrane cleavage of ∼150 substrates. Cleavage of amyloid precursor protein (APP)-derived substrate C99 generates 38–43-residue secreted amyloid β-peptides (Aβ), with the aggregation-prone 42-residue form (Aβ42) particularly implicate...
I tiakina i:
| Ngā kaituhi matua: | , , , |
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| Hōputu: | Artigo |
| Reo: | Inglês |
| I whakaputaina: |
Elsevier
2026-02-01
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| Rangatū: | Neurobiology of Disease |
| Ngā marau: | |
| Urunga tuihono: | http://www.sciencedirect.com/science/article/pii/S0969996126000112 |
| Ngā Tūtohu: |
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