Bifidobacterium infantis-mediated HSV-TK/GCV therapy modulates the tumor microenvironment through site-specific phosphorylation of HIF-1α, mTOR, and PD-L1
BackgroundBifidobacterium (BF)-mediated herpes simplex virus thymidine kinase (TK)/ganciclovir (GCV) therapy has shown antitumor activity, but its effects on protein phosphorylation remain unclear.MethodsQuantitative phosphoproteomic analysis was performed on HCT-116 tumor xenografts to identify pho...
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| Asıl Yazarlar: | , , , , |
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| Materyal Türü: | Artigo |
| Dil: | Inglês |
| Baskı/Yayın Bilgisi: |
Frontiers Media S.A.
2026-06-01
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| Seri Bilgileri: | Frontiers in Oncology |
| Konular: | |
| Online Erişim: | https://www.frontiersin.org/articles/10.3389/fonc.2026.1849164/full |
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