Bifidobacterium infantis-mediated HSV-TK/GCV therapy modulates the tumor microenvironment through site-specific phosphorylation of HIF-1α, mTOR, and PD-L1

BackgroundBifidobacterium (BF)-mediated herpes simplex virus thymidine kinase (TK)/ganciclovir (GCV) therapy has shown antitumor activity, but its effects on protein phosphorylation remain unclear.MethodsQuantitative phosphoproteomic analysis was performed on HCT-116 tumor xenografts to identify pho...

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Hlavní autoři:	Jiaming He, Yang Yuan, Jing Li, Yongping Ma, Dilong Chen
Médium:	Artigo
Jazyk:	Inglês
Vydáno:	Frontiers Media S.A. 2026-06-01
Edice:	Frontiers in Oncology
Témata:	BF-TK/GCV bifidobacterium infantis bioinformatics cancer phosphoproteomics transcriptomics
On-line přístup:	https://www.frontiersin.org/articles/10.3389/fonc.2026.1849164/full
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