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Genetic risk score informed re-evaluation of phenotype quality control to maximize power in epidemiological studies: application to lung function

Introduction Clinical guidelines may reduce statistical power in epidemiological studies by discarding informative measures. Epidemiological studies of lung function may discard one-third to one-half of participants due to spirometry measures deemed "low quality" using criteria adapted from clinica...

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Principais autores: Jing Chen, Nick Shrine, Abril G Izquierdo, Anna Guyatt, Alex Williams, Henry Völzke, Stephanie London, Ian P Hall, Frank Dudbridge, SpiroMeta Consortium, CHARGE Consortium, Louise V Wain, Martin D Tobin, Catherine John
Format: Artigo
Sprog:Inglês
Udgivet: Swansea University 2026-02-01
Serier:International Journal of Population Data Science
Fag:
epidemiological methods
genome-wide association study
data-driven quality control
spirometry quality control
genetic/polygenic risk score
Online adgang:https://ijpds.org/article/view/2997
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