Exome-wide analysis of copy number variation shows association of the human leukocyte antigen region with asthma in UK Biobank

Abstract Background The role of copy number variants (CNVs) in susceptibility to asthma is not well understood. This is, in part, due to the difficulty of accurately measuring CNVs in large enough sample sizes to detect associations. The recent availability of whole-exome sequencing (WES) in large b...

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Autors principals:	Katherine A. Fawcett, German Demidov, Nick Shrine, Megan L. Paynton, Stephan Ossowski, Ian Sayers, Louise V. Wain, Edward J. Hollox
Format:	Artigo
Idioma:	Inglês
Publicat:	BMC 2022-05-01
Col·lecció:	BMC Medical Genomics
Matèries:	Copy number variants Exome sequencing UK Biobank Asthma Genetic association Fine-mapping
Accés en línia:	https://doi.org/10.1186/s12920-022-01268-y
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