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The DNA sensors AIM2 and IFI16 are SLE autoantigens that bind neutrophil extracellular traps

Background: Nucleic acid binding proteins are frequently targeted as autoantigens in systemic lupus erythematosus (SLE) and other interferon (IFN)-linked rheumatic diseases. The AIM-like receptors (ALRs) are IFN-inducible innate sensors that form supramolecular assemblies along double-stranded (ds)D...

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Principais autores: Brendan Antiochos, Daniela Trejo-Zambrano, Paride Fenaroli, Avi Rosenberg, Alan Baer, Archit Garg, Jungsan Sohn, Jessica Li, Michelle Petri, Daniel W Goldman, Christopher Mecoli, Livia Casciola-Rosen, Antony Rosen
Format: Artigo
Sprog:Inglês
Udgivet: eLife Sciences Publications Ltd 2022-05-01
Serier:eLife
Fag:
autoimmunity
autoantibodies
neutrophil extracellular traps
Online adgang:https://elifesciences.org/articles/72103
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