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Simultaneous mass spectrometry imaging of multiple neuropeptides in the brain and alterations induced by experimental parkinsonism and L-DOPA therapy

Neuropeptides are important signalling molecules in the brain and alterations in their expression levels have been linked to neurological disorders such as Parkinson's disease. It is challenging to map neuropeptide changes across and within brain regions because of their low in vivo concentrations a...

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Principais autores: Heather Hulme, Elva Fridjonsdottir, Halla Gunnarsdottir, Theodosia Vallianatou, Xiaoqun Zhang, Henrik Wadensten, Reza Shariatgorji, Anna Nilsson, Erwan Bezard, Per Svenningsson, Per E. Andrén
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier 2020-04-01
coleção:Neurobiology of Disease
Assuntos:
Basal ganglia
Dynorphin
Enkephalin
L-DOPA
Mass spectrometry imaging
Neuropeptide
Acesso em linha:http://www.sciencedirect.com/science/article/pii/S0969996120300139
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