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Broad-Spectrum Inhibitors against Class A, B, and C Type β-Lactamases to Block the Hydrolysis against Antibiotics: Kinetics and Structural Characterization

ABSTRACT The emergence of antibiotic resistance has led to a global crisis for the physician to handle infection control issues. All antibiotics, including colistin, have lost efficiency against emerging drug-resistant bacterial strains due to the production of metallo-β-lactamases (MBLs) and serine...

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Principais autores: Nabeela Farhat, Divya Gupta, Abid Ali, Yogesh Kumar, Farheen Akhtar, Senthilguru Kulanthaivel, Prashant Mishra, Feroz Khan, Asad U. Khan
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2022-10-01
coleção:Microbiology Spectrum
Assuntos:
antibiotic resistance
MDR
β-lactam antibiotic
β-lactamases
β-lactamase inhibitors
NDM-1
Acesso em linha:https://journals.asm.org/doi/10.1128/spectrum.00450-22
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