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Effects of Human RelA Transgene on Murine Macrophage Inflammatory Responses

The NFκB transcription factors are major regulators of innate immune responses, and NFκB signal pathway dysregulation is linked to inflammatory disease. Here, we utilised bone marrow-derived macrophages from the p65-DsRedxp/IκBα-eGFP transgenic strain to study the functional implication of xenogenei...

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Principais autores: Stamatia Papoutsopoulou, Lorna Morris, Andrew Bayliff, Thomas Mair, Hazel England, Massimiliano Stagi, François Bergey, Mohammad Tauqeer Alam, Raheleh Sheibani-Tezerji, Philip Rosenstiel, Werner Müller, Vitor A. P. Martins Dos Santos, Barry J. Campbell
Formato: Artigo
Idioma:Inglês
Publicado: MDPI AG 2022-03-01
Series:Biomedicines
Assuntos:
macrophage
NFκB
RelA(p65)
inflammation
lipid A
lipopolysaccharide
Acceso en liña:https://www.mdpi.com/2227-9059/10/4/757
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