Molecular engineering improves antigen quality and enables integrated manufacturing of a trivalent subunit vaccine candidate for rotavirus

Abstract Background Vaccines comprising recombinant subunit proteins are well-suited to low-cost and high-volume production for global use. The design of manufacturing processes to produce subunit vaccines depends, however, on the inherent biophysical traits presented by an individual antigen of int...

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Autori principali:	Neil C. Dalvie, Joseph R. Brady, Laura E. Crowell, Mary Kate Tracey, Andrew M. Biedermann, Kawaljit Kaur, John M. Hickey, D. Lee Kristensen, Alexandra D. Bonnyman, Sergio A. Rodriguez-Aponte, Charles A. Whittaker, Marina Bok, Celina Vega, Tarit K. Mukhopadhyay, Sangeeta B. Joshi, David B. Volkin, Viviana Parreño, Kerry R. Love, J. Christopher Love
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	BMC 2021-05-01
Serie:	Microbial Cell Factories
Soggetti:	Pichia pastoris Subunit vaccine Quality by design Biomanufacturing
Accesso online:	https://doi.org/10.1186/s12934-021-01583-6
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