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Molecular Determinants for OMF Selectivity in Tripartite RND Multidrug Efflux Systems

Tripartite multidrug RND efflux systems made of an inner membrane transporter, an outer membrane factor (OMF) and a periplasmic adaptor protein (PAP) form a canal to expel drugs across Gram-negative cell wall. Structures of MexA–MexB–OprM and AcrA–AcrB–TolC, from <i>Pseudomonas aeruginosa</i> and <i...

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Main Authors: Esther Boyer, Jean Dessolin, Margaux Lustig, Marion Decossas, Gilles Phan, Quentin Cece, Grégory Durand, Véronique Dubois, Joris Sansen, Jean-Christophe Taveau, Isabelle Broutin, Laetitia Daury, Olivier Lambert
Format: Artigo
Language:Inglês
Published: MDPI AG 2022-01-01
Series:Antibiotics
Subjects:
antibiotic resistance
efflux pump
RND
Online Access:https://www.mdpi.com/2079-6382/11/2/126
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