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Microdialysis on Ex Vivo Porcine Ear Skin Can Validly Study Dermal Penetration including the Fraction of Transfollicular Penetration—Demonstrated on Caffeine Nanocrystals

Common ex vivo methods for penetration investigations often fail to monitor transfollicular penetration appropriately. In the present investigation, the validity of dermal microdialysis on the ex vivo porcine ear skin to investigate penetration kinetics, including transfollicular penetration, was st...

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Principais autores: Anna Lena Klein, Markus Lubda, David Specht, Sung-Min Pyo, Loris Busch, Jürgen Lademann, Martina C. Meinke, Ingeborg Beckers, Jörg von Hagen, Cornelia M. Keck, Alexa Patzelt
Format: Artigo
Sprog:Inglês
Udgivet: MDPI AG 2021-09-01
Serier:Nanomaterials
Fag:
transfollicular penetration
microdialysis
IVIVC
caffeine
drug delivery system
nanotechnology
Online adgang:https://www.mdpi.com/2079-4991/11/9/2387
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