Nanocrystal-loaded dissolving microneedles: A novel transdermal strategy for long-acting tizanidine administration

Spasticity is commonly managed with tizanidine (TZN), a centrally acting α2-adrenergic agonist. However, its clinical application is limited by poor oral bioavailability and a short elimination half-life, necessitating frequent dosing and thereby reducing patient adherence. In this study, a trilayer...

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Egile Nagusiak:	Yilin Cong, Huanhuan Li, Anjali Kiran Pandya, Lalitkumar K. Vora, Yaocun Li, Fabiana Volpe-Zanutto, Alejandro J. Paredes, Abraham M. Abraham, Jiaqi Gao, Eneko Larrañeta, Nuoya Qin, Yidan Luo, Yushi Tao, Brian Quinn, Helen O. McCarthy, Ryan F. Donnelly
Formatua:	Artigo
Hizkuntza:	Inglês
Argitaratua:	Elsevier 2025-12-01
Saila:	Materials Today Advances
Gaiak:	Tizanidine Spasticity Transdermal drug delivery Dissolving microneedle array patch Nanocrystal Long-acting delivery
Sarrera elektronikoa:	http://www.sciencedirect.com/science/article/pii/S2590049825000955
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