Nanocrystal-loaded dissolving microneedles: A novel transdermal strategy for long-acting tizanidine administration

Spasticity is commonly managed with tizanidine (TZN), a centrally acting α2-adrenergic agonist. However, its clinical application is limited by poor oral bioavailability and a short elimination half-life, necessitating frequent dosing and thereby reducing patient adherence. In this study, a trilayer...

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Autors principals:	Yilin Cong, Huanhuan Li, Anjali Kiran Pandya, Lalitkumar K. Vora, Yaocun Li, Fabiana Volpe-Zanutto, Alejandro J. Paredes, Abraham M. Abraham, Jiaqi Gao, Eneko Larrañeta, Nuoya Qin, Yidan Luo, Yushi Tao, Brian Quinn, Helen O. McCarthy, Ryan F. Donnelly
Format:	Artigo
Idioma:	Inglês
Publicat:	Elsevier 2025-12-01
Col·lecció:	Materials Today Advances
Matèries:	Tizanidine Spasticity Transdermal drug delivery Dissolving microneedle array patch Nanocrystal Long-acting delivery
Accés en línia:	http://www.sciencedirect.com/science/article/pii/S2590049825000955
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