TET knockout cells transit between pluripotent states and exhibit precocious germline entry

Abstract TET1, TET2 and TET3 are DNA demethylases with important roles in development and differentiation. To assess the contributions of TET proteins to cell function during early development, single and compound knockouts of Tet genes in mouse pluripotent embryonic stem cells (ESCs) were generated...

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Detalhes bibliográficos

Principais autores:	Raphaël Pantier, Elisa Barbieri, Sara Gonzalez Brito, Ella Thomson, Tülin Tatar, Douglas Colby, Man Zhang, Ian Chambers
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Springer Nature 2025-10-01
coleção:	The EMBO Journal
Assuntos:	Primordial Germ Cells TET Proteins Pluripotency Stem Cells Differentiation
Acesso em linha:	https://doi.org/10.1038/s44318-025-00597-9
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