Anomalous Salt Dependence Reveals an Interplay of Attractive and Repulsive Electrostatic Interactions in α-synuclein Fibril Formation

α-Synuclein (α-syn) is an intrinsically disordered protein with a highly asymmetric charge distribution, whose aggregation is linked to Parkinson’s disease. The effect of ionic strength was investigated at mildly acidic pH (5.5) in the presence of catalytic surfaces in the form of α-syn seeds or ani...

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Detalhes bibliográficos

Principais autores:	Ricardo Gaspar, Mikael Lund, Emma Sparr, Sara Linse
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Cambridge University Press 2020-01-01
coleção:	QRB Discovery
Assuntos:	Asymmetric charge distribution electrostatic interactions secondary nucleation protein aggregation self-assembly salt screening
Acesso em linha:	https://www.cambridge.org/core/product/identifier/S2633289220000071/type/journal_article
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