Targeting the histone H3 lysine 79 methyltransferase DOT1L in MLL-rearranged leukemias

Abstract Disrupting the methylation of telomeric silencing 1-like (DOT1L)-mediated histone H3 lysine 79 has been implicated in MLL fusion-mediated leukemogenesis. Recently, DOT1L has become an attractive therapeutic target for MLL-rearranged leukemias. Rigorous studies have been performed, and much...

Description complète

Détails bibliographiques

Auteurs principaux:	Yan Yi, Shenglei Ge
Format:	Artigo
Langue:	Inglês
Publié:	BMC 2022-03-01
Collection:	Journal of Hematology & Oncology
Sujets:	DOT1L MLL-rearranged leukemia Epigenetics Histone modifications Drug discovery Small molecule inhibitors
Accès en ligne:	https://doi.org/10.1186/s13045-022-01251-1
Tags:	Ajouter un tag Pas de tags, Soyez le premier à ajouter un tag!