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Long-term gabapentin treatment impairs cognitive function in aged mice via tau hyperphosphorylation

IntroductionGabapentin (GBP) is widely prescribed to older patients for pain management. Recent clinical studies highlight that GBP adversely affect cognitive function in older patients. GBP binds to the α2δ1 subunit of L-type voltage-gated Ca2+ channels to inhibit Ca2+ channel current. It is being...

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Furkejuvvon:
Váldodahkkit: Suyun Xia, Zerong You, Xinbo Wu, Jinsheng Yang, Shiyu Wang, Na Li, Jiajia Dai, Yuanlin Dong, Lucy Chen, Min Yan, Shiqian Shen, Zhongcong Xie, Jianren Mao
Materiálatiipa: Artigo
Giella:Inglês
Almmustuhtton: Frontiers Media S.A. 2025-09-01
Ráidu:Frontiers in Pharmacology
Fáttát:
aged mice
cognitive dysfunction
gabapentin (GBP)
tau
Sirt1
CaMKIIα
Liŋkkat:https://www.frontiersin.org/articles/10.3389/fphar.2025.1616775/full
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