Raf activation is regulated by tyrosine 510 phosphorylation in Drosophila.
The proto-oncoprotein Raf is pivotal for mitogen-activated protein kinase (MAPK) signaling, and its aberrant activation has been implicated in multiple human cancers. However, the precise molecular mechanism of Raf activation, especially for B-Raf, remains unresolved. By genetic and biochemical stud...
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| Hauptverfasser: | , , , , , , , , |
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| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
Public Library of Science (PLoS)
2008-05-01
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| Schriftenreihe: | PLoS Biology |
| Online-Zugang: | https://journals.plos.org/plosbiology/article/file?id=10.1371/journal.pbio.0060128&type=printable |
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