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Cognitive impairments in a Down syndrome model with abnormal hippocampal and prefrontal dynamics and cytoarchitecture

Summary: The Dp(10)2Yey mouse carries a ∼2.3-Mb intra-chromosomal duplication of mouse chromosome 10 (Mmu10) that has homology to human chromosome 21, making it an essential model for aspects of Down syndrome (DS, trisomy 21). In this study, we investigated neuronal dysfunction in the Dp(10)2Yey mou...

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Main Authors: Phillip M. Muza, Daniel Bush, Marta Pérez-González, Ines Zouhair, Karen Cleverley, Miriam L. Sopena, Rifdat Aoidi, Steven J. West, Mark Good, Victor L.J. Tybulewicz, Matthew C. Walker, Elizabeth M.C. Fisher, Pishan Chang
Format: Artigo
Language:Inglês
Published: Elsevier 2023-02-01
Series:iScience
Subjects:
Developmental neuroscience
Transcriptomics
Model organism
Online Access:http://www.sciencedirect.com/science/article/pii/S2589004223001505
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